Classification of Neurodevelopmental Age in Normal Infants Using 3D-CNN based on Brain MRI.
Shabanian M, Eckstein EC,
Chen H, DeVincenzo JP.
arXiv [eess.IV]. 2019.
ArXiv
Social and anxiety-like behaviors contribute to nicotine self-administration in adolescent outbred rats.
Wang T, Han W, Chitre AS, Polesskaya O, Solberg Woods LC, Palmer AA,
Chen H.
Sci Rep. 2018 Dec 24;8(1):18069.
PMC6305389
Genetic Model to Study the Co-Morbid Phenotypes of Increased Alcohol Intake and Prior Stress-Induced Enhanced Fear Memory.
Lim PH, Shi G, Wang T, Jenz ST, Mulligan MK, Redei EE,
Chen H.
Front Genet. 2018 Nov 27;9:566.
PMC6277590
Neurogenetic determinants and mechanisms of addiction to nicotine and smoked tobacco.
Sharp BM,
Chen H.
Eur J Neurosci. 2018 Sep 26;
PMID: 30256469
Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats.
Han W, Wang T,
Chen H.
Sci Rep. Nature Publishing Group; 2017 Aug 14;7(1):8052.
PMC5556091
An open source device for operant licking in rats.
Longley M, Willis EL, Tay CX,
Chen H.
PeerJ. 2017 Feb 14;5:e2981.
PMC5312574
A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer’s mouse model via an HSF1-mediated mechanism.
Wang B, Liu Y, Huang L, Chen J, Li JJ, Wang R, Kim E, Chen Y, Justicia C, Sakata K,
Chen H, Planas A, Ostrom RS, Li W, Yang G, McDonald MP, Chen R, Heck DH, Liao F-F.
Mol Psychiatry. 2016 Jul 26;
PMC5323357
Featured Article: Genotation: Actionable knowledge for the scientific reader.
Nagahawatte P, Willis E, Sakauye M, Jose R,
Chen H, Davis RL.
Exp Biol Med. 2016 Jun;241(11):1202–1209.
PMID: 26900164
Socially acquired nicotine self-administration with an aversive flavor cue in adolescent female rats.
Wang T, Han W,
Chen H.
Psychopharmacology. 2016 May;233(10):1837–1844.
PMC4846487
Synaptic plasticity in infralimbic cortex mediates socially-acquired nicotine self-administration.
Chen H, Wang T, Han W.
BMC Bioinformatics. BioMed Central; 2015;16(Suppl 15):P1.
PMC4625416
Carbon disulfide mediates socially-acquired nicotine self-administration.
Wang T,
Chen H.
PLoS One. 2014 Dec 22;9(12):e115222.
PMC4274004
Menthol facilitates the intravenous self-administration of nicotine in rats.
Wang T, Wang B,
Chen H.
Front Behav Neurosci. Frontiers; 2014 Dec 16;8:437.
PMC4267270
Social learning reverses conditioned aversion to nicotine via oxytocin receptor in the infralimbic cortex in rats (839.
Han W,
Chen H.
The FASEB Journal. 2014 Apr 1;28(1 Supplement).
Amplified reacquisition of nicotine self-administration in rats by repeated stress during abstinence.
Yu G,
Chen H, Sharp BM.
Psychopharmacology. 2014 Feb 21;
PMID: 24557090
Propensity for social interaction predicts nicotine-reinforced behaviors in outbred rats.
Wang T, Han W, Wang B, Jiang Q, Solberg-Woods LC, Palmer AA,
Chen H.
Genes Brain Behav. 2014 Feb;13(2):202–212.
PMC3934210
Evaluating statistical learning methods for cell type classification and feature selection using RNA-seq data.
Chen H.
BMC Bioinformatics. 2014;15(10):P26.
Full-gestational exposure to nicotine and ethanol augments nicotine self-administration by altering ventral tegmental dopaminergic function due to NMDA receptors in adolescent rats.
Roguski EE, Sharp BM,
Chen H, Matta SG.
J Neurochem. 2013 Nov 15;128(5):701–712.
PMID: 24147868
Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics.
Parker CC,
Chen H, Flagel SB, Geurts AM, Richards JB, Robinson TE, Solberg Woods LC, Palmer AA.
Neuropharmacology. 2013 Jun 18;76 Pt B:250–258.
PMC3823679
Fostering itself increases nicotine self-administration in young adult male rats.
Roguski EE,
Chen H, Sharp BM, Matta SG.
Psychopharmacology. 2013 May 17;229(2):227–234.
PMC3757107
Genetic factors control nicotine self-administration in isogenic adolescent rat strains.
Chen H, Hiler KA, Tolley EA, Matta SG, Sharp BM.
PLoS One. 2012 Aug 28;7(8):e44234.
PMC3429443
A promoter polymorphism in the Per3 gene is associated with alcohol and stress response.
Wang X, Mozhui K, Li Z, Mulligan MK, Ingels JF, Zhou X, Hori RT,
Chen H, Cook MN, Williams RW, Lu L.
Transl Psychiatry. 2012 Jan 31;2:e73.
PMC3309544
Genome-Wide Gene Expression Profiling of Nucleus Accumbens Neurons Projecting to Ventral Pallidum Using both Microarray and Transcriptome Sequencing.
Chen H, Liu Z, Gong S, Wu X, Taylor WL, Williams RW, Matta SG, Sharp BM.
Front Neurosci. 2011 Aug 12;5:98.
PMC3155868
Social interaction promotes nicotine self-administration with olfactogustatory cues in adolescent rats.
Chen H, Sharp BM, Matta SG, Wu Q.
Neuropsychopharmacology. 2011 Jul 27;36(13):2629–2638.
PMC3230486
Genetic dissection of the Gpnmb network in the eye.
Lu H, Wang X, Pullen M, Guan H,
Chen H, Sahu S, Zhang B, Chen H, Williams RW, Geisert EE, Lu L, Jablonski MM.
Invest Ophthalmol Vis Sci. 2011 Jun 13;52(7):4132–4142.
PMC3175941
Nicotine self-administration differentially modulates glutamate and GABA transmission in hypothalamic paraventricular nucleus to enhance the hypothalamic-pituitary-adrenal response to stress.
Yu G,
Chen H, Wu X, Matta SG, Sharp BM.
J Neurochem. 2010 Feb 25;113(4):919–929.
PMC2912162
Neuroadaptive changes in the mesocortical glutamatergic system during chronic nicotine self-administration and after extinction in rats.
Wang F,
Chen H, Sharp BM.
J Neurochem. 2008 May 3;106(2):943–956.
PMC2587995
Nicotine self-administration differentially regulates hypothalamic corticotropin-releasing factor and arginine vasopressin mRNAs and facilitates stress-induced neuronal activation.
Yu G,
Chen H, Zhao W, Matta SG, Sharp BM.
J Neurosci. 2008 Mar 12;28(11):2773–2782.
PMID: 18337407
Chronic nicotine self-administration augments hypothalamic-pituitary-adrenal responses to mild acute stress.
Chen H, Fu Y, Sharp BM.
Neuropsychopharmacology. 2007 Jun 6;33(4):721–730.
PMID: 17551542
Nicotine-induced norepinephrine release in hypothalamic paraventricular nucleus and amygdala is mediated by N-methyl-D-aspartate receptors and nitric oxide in the nucleus tractus solitarius.
Zhao R,
Chen H, Sharp BM.
J Pharmacol Exp Ther. 2006 Nov 8;320(2):837–844.
PMID: 17093131
Acquisition of nicotine self-administration in adolescent rats given prolonged access to the drug.
Chen H, Matta SG, Sharp BM.
Neuropsychopharmacology. 2006 Jun 14;32(3):700–709.
PMID: 16794562
Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships.
Bao L, Wei L, Peirce JL, Homayouni R, Li H, Zhou M,
Chen H, Lu L, Williams RW, Pfeffer LM, Goldowitz D, Cui Y.
Mamm Genome. 2006 Jun 12;17(6):575–583.
PMID: 16783639
Upregulation of ionotropic glutamate receptor subunits within specific mesocorticolimbic regions during chronic nicotine self-administration.
Wang F,
Chen H, Steketee JD, Sharp BM.
Neuropsychopharmacology. 2006 Feb 1;32(1):103–109.
PMC2587993
Integrative genetic analysis of transcription modules: towards filling the gap between genetic loci and inherited traits.
Li H,
Chen H, Bao L, Manly KF, Chesler EJ, Lu L, Wang J, Zhou M, Williams RW, Cui Y.
Hum Mol Genet. 2005 Dec 21;15(3):481–492.
PMID: 16371421
Gestational nicotine exposure reduces nicotinic cholinergic receptor (nAChR) expression in dopaminergic brain regions of adolescent rats.
Chen H, Parker SL, Matta SG, Sharp BM.
Eur J Neurosci. 2005 Jul;22(2):380–388.
PMID: 16045491
Content-rich biological network constructed by mining PubMed abstracts.
Chen H, Sharp BM.
BMC Bioinformatics. 2004 Oct 8;5:147.
PMC528731
Brain-derived neurotrophic factor reduces TrkB protein and mRNA in the normal retina and following optic nerve crush in adult rats.
Chen H, Weber AJ.
Brain Res. 2004 Jun 11;1011(1):99–106.
PMID: 15140649
Expression of glial fibrillary acidic protein and glutamine synthetase by Müller cells after optic nerve damage and intravitreal application of brain-derived neurotrophic factor.
Chen H, Weber AJ.
Glia. 2002 Apr 15;38(2):115–125.
PMID: 11948805
BDNF enhances retinal ganglion cell survival in cats with optic nerve damage.
Chen H, Weber AJ.
Invest Ophthalmol Vis Sci. 2001 Apr;42(5):966–974.
PMID: 11274073
Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus.
Weber AJ,
Chen H, Hubbard WC, Kaufman PL.
Invest Ophthalmol Vis Sci. 2000 May;41(6):1370–1379.
PMID: 10798652
Socially acquired nicotine i.v. self-administration in adolescent rats
Menthol as a conditioned reinforcer of nicotine reward
Menthol is the most common flavoring additive in tobacco and electronic cigarettes. Using licking as the operant behavior, we found that adolescent rats self-administering nicotine with contingent oral menthol obtained significantly more infusions than rats receiving a vehicle cue or rats self-administering i.v. saline with a menthol cue. Rats yoked to their menthol-nicotine masters emitted significantly fewer licks on the active spouts, indicating that contingent pairing between nicotine and menthol is required for sustained nicotine intake. These results provide a key behavioral mechanism by which menthol promotes the use of tobacco products or electronic cigarettes.
Genetic mapping of nicotine intake in rats
Oral oxycodone self-administration in rats
Pharmacokinetic factors are important contributors to the abuse liability of drugs. Oxycodone is the leading abused prescription drug, despite mostly being mostly taken orally. We are developing an oral oxycodone self-administration model in rats to study the genetic and neuronal mechanisms contributing to its addiction.
Sequencing rat genomes